Conduction in Nucleic Acid Components

Definitions and nomenclature of nucleic acid structure components.

We report here recommendations for the definitions and nomenclature of nucleic acid structure parameters. These recommendations result from discussions at an EMBO Workshop on DNA Curvature and Bending held at Churchill College, Cambridge, in September 1988.

Subtle interactions of cupric ion with nucleic acid and components.

In a study of the mechanism of activation of the copper enzyme, ascorbic acid oxidase, it was observed that most compounds which activate this enzyme have the common property of forming complex compounds with cupric ion (l-3). Among these activating substances were ribonucleic acid,’ deoxyribonucleic acid, and certain of their constituents. These substances showed a surprisingly strong affinity...

Solid-state NMR studies of nucleic acid components

Recent applications of solid-state NMR to the characterisation of nucleic acid systems are reviewed. Developments in NMR methodology and DFT-based first-principles calculations have led to the emergence of “NMR crystallography”, where solid-state NMR provides information on local structure and dynamics that complements information on periodic ordering and overall structure provided by tradition...

Reaction of diethyl pyrocarbonate with nucleic acid components. I. Adenine.

The use of diethyl pyrocarbonate as a nuclease inhibitor in the preparation of RNA of high molecular weight has prompted a study of the possible reactions of this compound with nucleic acid components under the conditions generally employed for providing inhibition. The first substrate investigated was adenine, which has been found to undergo ring opening with the formation of 5(4)-N-carbethoxy...

The nucleic acid of African Horse-Sickness Virus